67.4 Folate:B12
67.4.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
Prolactin| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 250.7924480 | 1 | <0.0001 | *** |
| Study | 3.2136720 | 1 | 0.07 | ns |
| f39_gdm_new | 0.5754347 | 1 | 0.4 | ns |
| BMI | 3.3368238 | 1 | 0.07 | ns |
| Ethnicity_cauc | 105.4219556 | 1 | <0.0001 | *** |
| f10c_any_cig_1st_vst | 49.1590682 | 1 | <0.0001 | *** |
| GA_samp | 164.6323095 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 1.8652579 | 1 | 0.2 | ns |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 150.8759535 | 1 | <0.0001 | *** |
| Study | 7.3986291 | 1 | 0.007 | ** |
| f39_gdm_new | 0.4357432 | 1 | 0.5 | ns |
| BMI | 236.2094019 | 1 | <0.0001 | *** |
| Ethnicity_cauc | 5.5165373 | 1 | 0.02 | * |
| f10c_any_cig_1st_vst | 0.9176455 | 1 | 0.3 | ns |
| GA_samp | 2601.9722143 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 1.4845286 | 1 | 0.2 | ns |
| Chisq | Df | Pr(>Chisq) | ||
|---|---|---|---|---|
| (Intercept) | 251.096669 | 1 | <0.0001 | *** |
| Study | 1.107622 | 1 | 0.3 | ns |
| f39_gdm_new | 1.386104 | 1 | 0.2 | ns |
| BMI | 87.622496 | 1 | <0.0001 | *** |
| Ethnicity_cauc | 3.246832 | 1 | 0.07 | ns |
| f10c_any_cig_1st_vst | 1.039153 | 1 | 0.3 | ns |
| GA_samp | 1032.266869 | 1 | <0.0001 | *** |
| Study:f39_gdm_new | 3.376951 | 1 | 0.07 | ns |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 21.326 | 21.326 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 33.726 | 33.726 | <0.0001 | *** |
| 4 | BMI | 1 | Inf | 330.722 | 330.722 | <0.0001 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 25.046 | 25.046 | <0.0001 | *** |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 3.158 | 3.158 | 0.08 | ns |
| 7 | GA_samp | 1 | Inf | 2.506 | 2.506 | 0.1 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 4.089 | 4.089 | 0.04 | * |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 36.051 | 36.051 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 32.027 | 32.027 | <0.0001 | *** |
| 4 | BMI | 1 | Inf | 316.807 | 316.807 | <0.0001 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 24.882 | 24.882 | <0.0001 | *** |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 2.618 | 2.618 | 0.1 | ns |
| 7 | GA_samp | 1 | Inf | 1.602 | 1.602 | 0.2 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 4.361 | 4.361 | 0.04 | * |
| model term | df1 | df2 | F.ratio | Chisq | p.value | ||
|---|---|---|---|---|---|---|---|
| 1 | Study | 1 | Inf | 53.182 | 53.182 | <0.0001 | *** |
| 3 | f39_gdm_new | 1 | Inf | 4.345 | 4.345 | 0.04 | * |
| 4 | BMI | 1 | Inf | 11.449 | 11.449 | 0.0007 | *** |
| 5 | Ethnicity_cauc | 1 | Inf | 0.718 | 0.718 | 0.4 | ns |
| 6 | f10c_any_cig_1st_vst | 1 | Inf | 0.028 | 0.028 | 0.9 | ns |
| 7 | GA_samp | 1 | Inf | 0.278 | 0.278 | 0.6 | ns |
| 2 | Study:f39_gdm_new | 1 | Inf | 1.558 | 1.558 | 0.2 | ns |
67.4.2 Model summary
Ratio of Geometric means (95% CI)
Prolactin| Var | Effect | P |
|---|---|---|
| (Intercept) | 2.75 (2.39, 3.11) | <0.0001 |
| folate_B12 | -0.00 (-0.00, 0.00) | 0.08 |
| f39_gdm_newGDM | -0.10 (-0.33, 0.13) | 0.38 |
| StudySTOP | -0.07 (-0.20, 0.05) | 0.25 |
| GA_samp | 0.14 (0.12, 0.16) | <0.0001 |
| folate_B12:f39_gdm_newGDM | 0.00 (-0.00, 0.00) | 0.79 |
| f39_gdm_newGDM:StudySTOP | 0.16 (-0.07, 0.38) | 0.17 |
| folate_B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.09 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 0.64 (0.46, 0.83) | <0.0001 |
| folate_B12 | -0.00 (-0.00, 0.00) | 0.71 |
| f39_gdm_newGDM | -0.07 (-0.18, 0.04) | 0.24 |
| StudySTOP | 0.11 (0.04, 0.18) | 0.001 |
| GA_samp | 0.29 (0.28, 0.30) | <0.0001 |
| folate_B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.84 |
| f39_gdm_newGDM:StudySTOP | 0.06 (-0.05, 0.18) | 0.27 |
| folate_B12:StudySTOP | -0.00 (-0.00, 0.00) | 0.53 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | -2.55 (-2.80, -2.30) | <0.0001 |
| folate_B12 | -0.00 (-0.00, -0.00) | 0.01 |
| f39_gdm_newGDM | -0.16 (-0.32, 0.01) | 0.06 |
| StudySTOP | -0.03 (-0.12, 0.06) | 0.48 |
| GA_samp | 0.26 (0.25, 0.28) | <0.0001 |
| folate_B12:f39_gdm_newGDM | 0.00 (-0.00, 0.00) | 0.77 |
| f39_gdm_newGDM:StudySTOP | 0.17 (0.00, 0.33) | 0.05 |
| folate_B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.62 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 2.39 (1.93, 2.85) | <0.0001 |
| folate_B12 | 0.00 (-0.00, 0.00) | 0.87 |
| f39_gdm_newGDM | 0.79 (0.34, 1.23) | 0.0005 |
| StudySTOP | -0.19 (-0.36, -0.02) | 0.03 |
| GA_samp | 0.02 (-0.01, 0.05) | 0.20 |
| folate_B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.98 |
| f39_gdm_newGDM:StudySTOP | -0.28 (-0.76, 0.21) | 0.27 |
| folate_B12:StudySTOP | -0.00 (-0.00, 0.00) | 0.25 |
| folate_B12:f39_gdm_newGDM:StudySTOP | 0.00 (-0.00, 0.00) | 0.94 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.02 (0.53, 1.50) | <0.0001 |
| folate_B12 | 0.00 (-0.00, 0.00) | 0.89 |
| f39_gdm_newGDM | 0.91 (0.41, 1.40) | 0.0003 |
| StudySTOP | -0.34 (-0.52, -0.16) | 0.0003 |
| GA_samp | 0.02 (-0.01, 0.05) | 0.32 |
| folate_B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.81 |
| f39_gdm_newGDM:StudySTOP | -0.36 (-0.90, 0.19) | 0.20 |
| folate_B12:StudySTOP | -0.00 (-0.00, 0.00) | 0.25 |
| folate_B12:f39_gdm_newGDM:StudySTOP | 0.00 (-0.00, 0.00) | 0.84 |
| Var | Effect | P |
|---|---|---|
| (Intercept) | 1.72 (1.62, 1.81) | <0.0001 |
| folate_B12 | 0.00 (-0.00, 0.00) | 0.94 |
| f39_gdm_newGDM | 0.14 (0.01, 0.27) | 0.03 |
| StudySTOP | -0.15 (-0.18, -0.11) | <0.0001 |
| GA_samp | -0.00 (-0.01, 0.00) | 0.52 |
| folate_B12:f39_gdm_newGDM | -0.00 (-0.00, 0.00) | 0.18 |
| f39_gdm_newGDM:StudySTOP | -0.08 (-0.19, 0.04) | 0.18 |
| folate_B12:StudySTOP | 0.00 (-0.00, 0.00) | 0.57 |
67.4.3 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:B12 ratio and may be misleading when interaction term is involved.
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 97.20412 | 7.281342 | 86.51760 | 83.75653 | 112.8108 |
| STOP | non-GDM | 95.58684 | 6.831944 | 71.92643 | 82.89315 | 110.2243 |
| SCOPE | GDM | 88.72606 | 10.976535 | 527.10852 | 69.58321 | 113.1352 |
| STOP | GDM | 102.20950 | 8.817559 | 148.76685 | 86.18988 | 121.2066 |
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 89.39632 | 2.386189 | 154.4630 | 84.80467 | 94.23659 |
| STOP | non-GDM | 98.68489 | 2.406359 | 109.2051 | 94.02907 | 103.57123 |
| SCOPE | GDM | 83.02221 | 4.493204 | 800.7892 | 74.65469 | 92.32759 |
| STOP | GDM | 97.59695 | 3.506629 | 407.6971 | 90.94143 | 104.73956 |
| Study | f39_gdm_new | response | SE | df | lower.CL | upper.CL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 2.349434 | 0.0669864 | 371.0951 | 2.221338 | 2.484917 |
| STOP | non-GDM | 2.302558 | 0.0555231 | 236.1645 | 2.195732 | 2.414582 |
| SCOPE | GDM | 2.025946 | 0.1537443 | 1373.2989 | 1.745722 | 2.351151 |
| STOP | GDM | 2.343037 | 0.0992274 | 751.0354 | 2.156119 | 2.546160 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 14.12243 | 0.6925753 | Inf | 12.82820 | 15.54723 |
| STOP | non-GDM | 11.08270 | 0.4161006 | Inf | 10.29644 | 11.92900 |
| SCOPE | GDM | 30.92614 | 4.9114459 | Inf | 22.65398 | 42.21889 |
| STOP | GDM | 18.56835 | 1.4196529 | Inf | 15.98433 | 21.57011 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 3.418868 | 0.1780292 | Inf | 3.087152 | 3.786226 |
| STOP | non-GDM | 2.307994 | 0.0911998 | Inf | 2.135992 | 2.493846 |
| SCOPE | GDM | 8.231226 | 1.4380393 | Inf | 5.844603 | 11.592417 |
| STOP | GDM | 4.003332 | 0.3292095 | Inf | 3.407407 | 4.703479 |
| Study | f39_gdm_new | response | SE | df | asymp.LCL | asymp.UCL |
|---|---|---|---|---|---|---|
| SCOPE | non-GDM | 5.425348 | 0.0505319 | Inf | 5.327206 | 5.525298 |
| STOP | non-GDM | 4.708502 | 0.0360794 | Inf | 4.638316 | 4.779750 |
| SCOPE | GDM | 6.079494 | 0.3285876 | Inf | 5.468412 | 6.758863 |
| STOP | GDM | 4.880484 | 0.0623350 | Inf | 4.759827 | 5.004201 |
67.4.4 Comparisons
67.4.4.1 Within Groups
Effect for every 100 unit increase in Folate:B12 ratio.| Hormone | Contrast | Study | f39_gdm_new | Ratio of Geometric means (95% CI) | P-value |
|---|---|---|---|---|---|
| Prolactin | folate_B12245.96 / folate_B12145.96 | SCOPE | non-GDM | 0.979 (0.956, 1.003) | 0.08 |
| Prolactin | folate_B12245.96 / folate_B12145.96 | STOP | non-GDM | 1.008 (0.983, 1.033) | 0.5 |
| Prolactin | folate_B12245.96 / folate_B12145.96 | SCOPE | GDM | 0.985 (0.937, 1.036) | 0.6 |
| Prolactin | folate_B12245.96 / folate_B12145.96 | STOP | GDM | 1.014 (0.973, 1.057) | 0.5 |
| HPL | folate_B12245.96 / folate_B12145.96 | SCOPE | non-GDM | 0.998 (0.985, 1.010) | 0.7 |
| HPL | folate_B12245.96 / folate_B12145.96 | STOP | non-GDM | 0.992 (0.978, 1.005) | 0.2 |
| HPL | folate_B12245.96 / folate_B12145.96 | SCOPE | GDM | 0.995 (0.969, 1.022) | 0.7 |
| HPL | folate_B12245.96 / folate_B12145.96 | STOP | GDM | 0.989 (0.967, 1.012) | 0.3 |
| GH2 | folate_B12245.96 / folate_B12145.96 | SCOPE | non-GDM | 0.978 (0.961, 0.996) | 0.01 |
| GH2 | folate_B12245.96 / folate_B12145.96 | STOP | non-GDM | 0.984 (0.966, 1.003) | 0.1 |
| GH2 | folate_B12245.96 / folate_B12145.96 | SCOPE | GDM | 0.983 (0.947, 1.021) | 0.4 |
| GH2 | folate_B12245.96 / folate_B12145.96 | STOP | GDM | 0.990 (0.959, 1.021) | 0.5 |
| Insulin | folate_B12245.96 / folate_B12145.96 | SCOPE | non-GDM | 1.003 (0.967, 1.040) | 0.9 |
| Insulin | folate_B12245.96 / folate_B12145.96 | STOP | non-GDM | 0.976 (0.949, 1.004) | 0.09 |
| Insulin | folate_B12245.96 / folate_B12145.96 | SCOPE | GDM | 1.002 (0.913, 1.099) | 1.0 |
| Insulin | folate_B12245.96 / folate_B12145.96 | STOP | GDM | 0.979 (0.927, 1.034) | 0.4 |
| HOMA.IR | folate_B12245.96 / folate_B12145.96 | SCOPE | non-GDM | 1.003 (0.965, 1.041) | 0.9 |
| HOMA.IR | folate_B12245.96 / folate_B12145.96 | STOP | non-GDM | 0.975 (0.946, 1.004) | 0.09 |
| HOMA.IR | folate_B12245.96 / folate_B12145.96 | SCOPE | GDM | 0.987 (0.879, 1.109) | 0.8 |
| HOMA.IR | folate_B12245.96 / folate_B12145.96 | STOP | GDM | 0.973 (0.918, 1.033) | 0.4 |
| GLUC3_mmol.L | folate_B12245.96 / folate_B12145.96 | SCOPE | non-GDM | 1.000 (0.994, 1.006) | 0.9 |
| GLUC3_mmol.L | folate_B12245.96 / folate_B12145.96 | STOP | non-GDM | 1.004 (0.995, 1.012) | 0.4 |
| GLUC3_mmol.L | folate_B12245.96 / folate_B12145.96 | SCOPE | GDM | 0.986 (0.961, 1.010) | 0.3 |
| GLUC3_mmol.L | folate_B12245.96 / folate_B12145.96 | STOP | GDM | 0.989 (0.973, 1.006) | 0.2 |
67.4.4.2 Between Groups
Below are comparisons of the differences in the change in Folate:B12 ratio between groups. I.e. whether the change in Folate:B12 ratio are different between groups.
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.059647 | 0.0365028 | 2086.782 | 0.9904256 | 1.133706 | 0.093 | ns |
| STOP/SCOPE (non-GDM) | 1.029392 | 0.0177303 | 2086.782 | 0.9952013 | 1.064756 | 0.093 | ns |
| STOP/SCOPE (GDM) | 1.029392 | 0.0177303 | 2086.782 | 0.9952013 | 1.064756 | 0.093 | ns |
| GDM/non-GDM (SCOPE) | 1.006263 | 0.0239070 | 1986.639 | 0.9604531 | 1.054258 | 0.793 | ns |
| GDM/non-GDM (STOP) | 1.006263 | 0.0239070 | 1986.639 | 0.9604531 | 1.054258 | 0.793 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 0.9885105 | 0.0182531 | 1977.580 | 0.9533537 | 1.024964 | 0.532 | ns |
| STOP/SCOPE (non-GDM) | 0.9942387 | 0.0091794 | 1977.580 | 0.9763983 | 1.012405 | 0.532 | ns |
| STOP/SCOPE (GDM) | 0.9942387 | 0.0091794 | 1977.580 | 0.9763983 | 1.012405 | 0.532 | ns |
| GDM/non-GDM (SCOPE) | 0.9974014 | 0.0126798 | 1827.563 | 0.9728405 | 1.022582 | 0.838 | ns |
| GDM/non-GDM (STOP) | 0.9974014 | 0.0126798 | 1827.563 | 0.9728405 | 1.022582 | 0.838 | ns |
| contrast | ratio | SE | df | lower.CL | upper.CL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.012904 | 0.0260314 | 2086.194 | 0.9631187 | 1.065262 | 0.618 | ns |
| STOP/SCOPE (non-GDM) | 1.006431 | 0.0129325 | 2086.194 | 0.9813861 | 1.032115 | 0.618 | ns |
| STOP/SCOPE (GDM) | 1.006431 | 0.0129325 | 2086.194 | 0.9813861 | 1.032115 | 0.618 | ns |
| GDM/non-GDM (SCOPE) | 1.005274 | 0.0178169 | 1979.419 | 0.9709322 | 1.040830 | 0.767 | ns |
| GDM/non-GDM (STOP) | 1.005274 | 0.0178169 | 1979.419 | 0.9709322 | 1.040830 | 0.767 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 0.9513796 | 0.0568495 | Inf | 0.8462341 | 1.069590 | 0.404 | ns |
| STOP/SCOPE (non-GDM) | 0.9732677 | 0.0228460 | Inf | 0.9295049 | 1.019091 | 0.248 | ns |
| STOP/SCOPE (GDM) | 0.9775107 | 0.0537323 | Inf | 0.8776720 | 1.088706 | 0.679 | ns |
| GDM/non-GDM (SCOPE) | 0.9985106 | 0.0508678 | Inf | 0.9036274 | 1.103357 | 0.977 | ns |
| GDM/non-GDM (STOP) | 1.0028636 | 0.0313648 | Inf | 0.9432360 | 1.066261 | 0.927 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 0.9584520 | 0.0681427 | Inf | 0.8337825 | 1.101762 | 0.551 | ns |
| STOP/SCOPE (non-GDM) | 0.9722000 | 0.0240018 | Inf | 0.9262774 | 1.020399 | 0.253 | ns |
| STOP/SCOPE (GDM) | 0.9858588 | 0.0657369 | Inf | 0.8650810 | 1.123499 | 0.831 | ns |
| GDM/non-GDM (SCOPE) | 0.9848630 | 0.0615982 | Inf | 0.8712394 | 1.113305 | 0.807 | ns |
| GDM/non-GDM (STOP) | 0.9986997 | 0.0337874 | Inf | 0.9346254 | 1.067167 | 0.969 | ns |
| contrast | ratio | SE | df | asymp.LCL | asymp.UCL | p.value | |
|---|---|---|---|---|---|---|---|
| SCOPE/SCOPE (Overall) | 1.0067462 | 0.0119709 | Inf | 0.9835551 | 1.030484 | 0.572 | ns |
| STOP/SCOPE (non-GDM) | 1.0033674 | 0.0059653 | Inf | 0.9917434 | 1.015128 | 0.572 | ns |
| STOP/SCOPE (GDM) | 1.0033674 | 0.0059653 | Inf | 0.9917434 | 1.015128 | 0.572 | ns |
| GDM/non-GDM (SCOPE) | 0.9853927 | 0.0108380 | Inf | 0.9643779 | 1.006865 | 0.181 | ns |
| GDM/non-GDM (STOP) | 0.9853927 | 0.0108380 | Inf | 0.9643779 | 1.006865 | 0.181 | ns |